Registration Dossier

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Administrative data

Key value for chemical safety assessment

Additional information

Endpoint Conclusion:

Justification for classification or non-classification

Triboron trimethyl hexaoxide is expected to hydrolyse in contact with water to form methanol (CAS 67-56-1) and boric acid (CAS 10043-35-3) (Steinberg and Hunter, 1957). For both hydrolysis products relevant genetic toxicity data was gathered from the ECHA dissemination dossier (d.d. 2014 -04 -25) and tabulated below. The classification of the parent substance is based on the worst case classification of both hydrolysis products.

 

Genetic toxicity data for methanol:

 

Study

Species

Type of method

Result

Gene mutation (Ames test)

S. typhimurium and E.coli

In vitro

Negative

Gene mutation

Chinese hamster lung fibroblasts (V79)

In vitro

Negative

Chromosome aberration

Chinese hamster lung fibroblasts (V79)

In vitro

Negative

Chromosome aberration

Mouse

In vivo

Negative

 

Genetic toxicity data for boric acid:

 

Study

Species

Type of method

Result

Gene mutation (Ames test)

S. typhimurium

In vitro

Negative

Gene mutation

Mouse lymphoma L5178Y cells

In vitro

Negative

DNA damage and/or repair

Chinese hamster Ovary (CHO)

In vitro

Negative

Chromosome aberration

Mouse

In vivo

Negative

 

 

In accordance with Regulation EC/1272/2008 and Directive 67/548/EEC, methanol and boric acid are not considered to be classified for genetic toxicity.

Triboron trimethyl hexaoxide does not need to be classified for genetic toxicity in accordance with Regulation EC/1272/2008 and Directive 67/548/EEC.

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