Registration Dossier
Registration Dossier
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EC number: 201-755-0 | CAS number: 87-59-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Some older Ames-Test studies for the test substance (BUA Stoffbericht 161) support the results of the key studies. 2,3 -dimethylanlin is considered as weakly mutagenic. Metabolic activation is essentiell to induce effect. Supporting studies of genotxicity (BUA Stoffbericht 161, p. 144 -145) show weak genotoxic potential of substance.
Short description of key information:
In newer key studies 2,3-Dimethylaniline was mutagenic in Salmonella typhimurium TA100, with an exogeneous metabolic activation system.
Genotoxicity of 2,3-dimethylaniline was studied by chromosomal aberration test in cultured Chinese hamster lung (CHL/IU) cells.
Structural chromosomal aberrations were induced at 0.60 mg/ml (high concentration) in the short-term treatment with an exogenous metabolic activation system. Polyploidy was not induced in any treatment groups.
Endpoint Conclusion:
Justification for classification or non-classification
The results are not considered as sufficient for classification.
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