2-ethoxyphenol

Boiling point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

from 09 february 2010 to 22 november 2010

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: GLP study, OECD 103 compliant. This study was disregarded, because the boiling point observed does not correspond to the real boiling point of Guetol, but the evaporation of a light component or to the slight degradation of the sample

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Boiling pt.:

113.4 °C

Atm. press.:

1 013 hPa

Decomposition:

no

Remarks on result:

other: This temperature does not correspond to the boiling point of Guetol itself but to the evaporation of a light component or to the slight degradation of the sample

Complementary assay

A volume of 15 mL of GUETOL was sampled in a 25-mL volumetric flask. The solution was heated on a hot plate. From 100 °C, some movements or perturbations appeared in the flask with a very light reflux on the sides of the flask.

An intensification of the reflux was observed from 100 to 175 °C. From 175 °C, the colour of the solution became clear yellow to yellow.

At 190 °C, the solution boiled.

Conclusions:

The boiling point observed does not correspond to the real boiling point of the substance.

Executive summary:

In a study (Defitraces, 2010), the boiling point of guetol was determined according to OECD 103 guideline and GLP, using the Differential Scanning Calorimetry (DSC) method.

In this study, the mean boiling point of the test item was determined on 2 assays at 113.4 ± 0.5°C.

But this temperature does not correspond to the boiling point of Guetol itself but to the evaporation of a light component or to the slight degradation of the sample, as measured by other techniques and during industrial process measurement in Rhodia Saint-Fons plant.

Reference 2

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

july 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The boiling point observed was not the real boiling point due to disturbances during the test. The results were slightly higher than the literature data.

Qualifier:

no guideline followed

Guideline:

other: VSP measurement

Principles of method if other than guideline:

The objective is to determine the pression curve of test item Guetol, to deduce its boiling point at atmospheric pressure.

GLP compliance:

no

Type of method:

other: VSP measurement

Two assays were made in two different sample of Guetol. The same observations were made in both.

The curve "Pression corrigée des inertes en échelle logarithmique en fonction de la température en échelle réciproque" which would correspond to vapour pression curve of the test item, was disturbed and did not permit to secure the value of boiling point at atmospheric pressure.

It was established that the product undergoes transformations during the heating, that have an effect on vapour pressure curve by decreasing the vapour pressure.

The boiling points observed were from 234.1 to 235.6°C, slightly above the 217°C given by literature.

Conclusions:

The measurements obtained were not the real boiling point, due to disturbances of the curves during the test which was caused by evaporation of a light component or to the slight degradation of the sample during the test.

Executive summary:

In a study (CRTL, 2010), the boiling point of Guetol was determined by VSP measurement.

The curve "Pression corrigée des inertes en échelle logarithmique en fonction de la température en échelle réciproque" which would correspond to vapour pression curve of the test item, was disturbed and did not permit to secure the value of boiling point at atmospheric pressure.

It was established that the product undergoes transformations during the heating, that have an effect on vapour pressure curve by decreasing the vapour pressure.

The boiling points observed were from 234.1 to 235.6°C, slightly above the 217°C given by literature.

It was concluded that literature data are more acurate and should serve as reference for boiling point of Guetol.

Reference 3

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

No test substance information, no guideline, secondary literature, but reference database, and handbooks.

Guideline:

other: no data

GLP compliance:

no

Type of method:

other: not specified

Boiling pt.:

216.5 - 217 °C

Remarks on result:

other: no additioonal data provided

Values measured in the different sources: 490.2K      source : CRC Handbook

490.0K      source : Buckingham et al.

489.7K      source : Lecat, M.

No more data.

Description of key information

Boiling point range: 216.5 to 217°C, based on literature data.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

217 °C

Additional information

In the experimental study (Defitraces 2010), the mean corrected boiling point of the test item was determined on 2 assays at 113.4 ± 0.5 °C, by DSC.

 

This temperature does not correspond to the boiling point of Guetol itself but to the evaporation of a light component or to the slight degradation of the sample, as confirmed by other techniques (CRTL/DEPT/HSEM/2010/0100,20/07/2010, Température d’ébullition atmosphérique du Guétol. Mesure en VSP).

 

It is therefore preferable to refer to the boiling points of Guetol given in the literature, selected as key studies, with values from 216.5 to 217°C at atmospheric pressure; these values are in agreement with the boiling point observed in the industrial process: 123°C at 58,5 hPa.