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EC number: 202-607-8 | CAS number: 97-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 11.1 mg/kg bw/day
Additional information
Due to the lack of available data, the potential of disulfiram to affect fertility is assessed using read-across from studies conducted with a surrogate substance, thiram (CAS 137 -26 -8). After correction for molecular weight (factor: 1.23) the NOAELs for thiram are used as NAELs for disulfiram. (For detailed information on the justification of read-across, please refer to the analogue justification document attached in IUCLID section 13).
One GLP-compliant two-generation study was conducted with thiram in rats (, 1991). Animals of all generations were administered 30, 60 or 180 ppm disulfiram in the diet.At the parental level, there were no treatment-related findings concerning mortality, ante mortem observations and reproductive parameters, e. g. copulatory, fertility and gestation indices, mean copulatory interval, mean gestation length as well as sperm morphology and motility. Food consumption and body weight decreased in groups dosed with 60 and 180 ppm, mainly during gestation. With regard to the litters, there were no treatment-related findings concerning the number of stillborn pups, survival indices, necropsy findings or malformations. Under the conditions of this study the NOAEL for reproductive toxicity was greater than 9 mg/kg bw/day. Based on the molecular weight, this refers to a NAEL of 11.1 mg/kg bw/day for disulfiram.
Short description of key information:
Based on the read-across from thiram, a NOAEL of 11.1 is derived by correcting the NOAEL of 9 mg/kg bw/d for thiram with the correction factor of 1.23 for molecular weight.
Effects on developmental toxicity
Description of key information
Based on read-across with thiram, it is expected that disulfiram has no specific effects on pre-natal development in rats or rabbits.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 18.5 mg/kg bw/day
Additional information
The developmental toxicity / teratogenicity of disulfiram is assessed using read-across from studies conducted with a surrogate substance, thiram (CAS 137 -26 -8). After correction for molecular weight (factor: 1.23) the NOAELs for thiram are used as NAELs for disulfiram. (For detailed information on the justification of read-across, please refer to the analogue justification document attached in IUCLID section 13).
Prenatal developmental toxicity studies according to OECD or EPA guidelines were performed in rabbits (York, 1992, Tesh, 1988) and rats (Tesh, 1988). In these studies, pregnant rabbits were dosed with up to and including 10 mg thiram /kg bw/d during gestation days 7 to 19. Based on the results of the study performed by, (1992), the foetal NOAEL is considered to be ≥ 10 mg/kg bw/day in rabbits given thiram via oral gavage, with the maternal NOAEL being as well ≥ 10 mg/kg bw/day. In the presence of maternal toxicity, Tesh (1988) reported a developmental NOAEL of 5 mg/kg bw/d. 25 pregnant rats per group were dosed with 7.5, 15 and 30 mg thiram/kg bw/d during gestation days 6 to 15. Based on a high incidence of small foetuses and an associated retardation of foetal development in the high dose group, the NOAEL is considered to be 15 mg/kg bw/day in rat. Based on the molecular weight this refers to a NAEL of 18.5 mg/kg bw/day for disulfiram.
Justification for classification or non-classification
The available data on toxicity to reproduction is conclusive but not sufficient for classification according to the EU Directive 67/548/EEC and the CLP Regulation.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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