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EC number: 202-607-8 | CAS number: 97-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
TETD (tetraethylthiuram disulphide, Disulfiram, CAS 97-77-8) is very toxic to aquatic organisms regarding acute and long term exposition.
Additional information
For the assessment of the aquatic toxicity of TETD (tetraethylthiuram disulphide, Disulfiram, CAS 97-77-8), experimental studies are available, which cover the short-term toxicity to all three trophic levels (fish, aquatic invertebrates and algae) and the long-term toxicity of two trophic level aquatic algae and Daphnia. All studies were performed according to the internationally accepted OECD guidelines and GLP.
The acute studies of algae, daphnia and fish resulted in an LC50 (96 h) of 0.067 mg/L (nominal), EC50 (48 h) of 0.150 mg/L (nominal) and EC50 (72 h) of >1.68 mg/L (based on geometric mean measured concentrations), respectively. Chronic data are available for algae and daphnia with an EC10 (72 h) values of 1.05 mg/L for the algae and an EC10 value of 0.00264 mg/L (based on the measured concentrations) for the chronic Daphnia.
Based on the acute data, the most sensitive species was expected to be the chronic fish. However, due to analytical problems, the main test for the chronic fish test was considered as technically not feasible. An OECD 210 range finding study was run but the main test was cancelled as a pervasive background attributable to the test substance was observed throughout the test. The effects was as such, that no clear analytical dose verification was possible for the chronic fish test. Available results from the range-finding test on fish indicated that at least a nominal concentration of 1 to 10 µg/L would be required for the definitive test with the NOEC being in the range of 1 µg/L, which is within the same range as the chronic Daphnia study. Due to the impossibility to conduct the chronic fish test with appropriate analytical verification, the PNEC for TETD was therefore derived based on the long term daphnia study with an EC10 value of 0.00264 mg/L (measured concentration).
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