Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The inhalation toxicity of phenylglycidyl ether. 1. 90-day inhalation study
- Author:
- Terrill JB, Lee KP
- Year:
- 1 977
- Bibliographic source:
- Toxicol Appl Pharmacol 42, 263-269
- Reference Type:
- secondary source
- Title:
- Toxicological Evaluations 3 - Potential health hazards of existing chemicals
- Author:
- BG Chemie
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- very limited documentation
- Test type:
- standard acute method
Test material
- Reference substance name:
- phenyl glcyidyl ether
- IUPAC Name:
- phenyl glcyidyl ether
- Details on test material:
- - Name of test material (as cited in study report): phenyl glcyidyl ether
No further information.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 250-260 g
No further information.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- No data.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- No data.
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC100
- Effect level:
- 323 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No data.
- Clinical signs:
- other: No data.
- Body weight:
- In surviving rats, loss of body weight was observed.
- Gross pathology:
- Severe irritation of the scrotum was observed in rats that survived.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
