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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 930-986-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Principles of method if other than guideline:
- Plate incorporation assay with six doses tested in four Salmonella strains (TA98, TA100, TA1535, TA1537) and E. coli WP2 (uvrA).
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): Zeolite S-D (H-Mordenite)
- Framework: orthorhombic
- Related CAS number: 1318-02-1
- Analytical purity: no data
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA98, TA100, TA1535 and TA 1537, and E. coli WP2 (uvrA)
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix contained 10% v/v S9 from male Sprague-Dawley rats induced by PB and BF
- Test concentrations with justification for top dose:
- 0.156, 0.313, 0.625, 1.25, 2.5 and 5 mg/plate
- Vehicle / solvent:
- diluted in distilled water with sonication
Controls
- Untreated negative controls:
- not specified
- Remarks:
- (vehicle control used as negative control)
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: -S9 mix: AF-2 (TA100: 0.01, TA98: 0.1, and E. coli WP2: 0.01 μg/plate), ENNG (TA1535: 5 μg/plate), ICR-191 (TA1537: 1 μg/plate); +S9mix: 2-aminoanthracene for all strains (AF-2: 1, TA1535: 2, WP2: 20, TA98: 0.5, TA1537: 2 μg/plate)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48 hours at 37 °C
- Expression time (cells in growth medium): 16 hours
NUMBER OF REPLICATIONS: 2
NUMBER OF CELLS EVALUATED: Yes
DETERMINATION OF CYTOTOXICITY
- Method: observed but no information of method
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium TA98, TA100, TA1535 and TA 1537, and E. coli WP2 (uvrA)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Additional information on results:
- There were no increased incidence of reverse mutations observed in all tester strains when compared to controls. H-Mordenite was found to be non-mutagenic in this assay. The positive controls gave appropriate responses.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 1. Mean colony number per plate
|
Concentration (μg/ plate) |
TA100 |
TA1535 |
WP2uvrA |
TA98 |
TA1537 |
S9 Mix (-) |
Control |
204 |
16 |
20 |
12 |
9 |
156 |
156 |
16 |
20 |
10 |
6 |
|
313 |
192 |
15 |
19 |
8 |
6 |
|
625 |
200 |
16 |
18 |
10 |
7 |
|
1250 |
188 |
21 |
24 |
17 |
9 |
|
2500 |
212 |
22 |
22 |
18 |
15 |
|
5000 |
188 |
26 |
26 |
20 |
16 |
|
S9 Mix (+) |
Control |
176 |
10 |
15 |
30 |
6 |
156 |
174 |
12 |
18 |
30 |
8 |
|
313 |
136 |
10 |
19 |
30 |
4 |
|
625 |
152 |
10 |
18 |
28 |
8 |
|
1250 |
154 |
12 |
17 |
22 |
10 |
|
2500 |
186 |
12 |
12 |
24 |
10 |
|
5000 |
160 |
15 |
20 |
26 |
6 |
|
Positive control (S9-) |
|
AF-2 0.01 μg/ plate |
ENNG 5 μg/ plate |
AF-2 0.01 μg/ plate |
AF-2 0.1 μg/ plate |
ICR-191 1 μg/ plate |
470 |
105 |
226 |
329 |
394 |
||
Positive control (S9+) |
|
2-AA 1 μg/ plate |
2-AA 2 μg/ plate |
2-AA 20 μg/ plate |
2-AA 0.5 μg/ plate |
2-AA 2 μg/ plate |
340 |
234 |
444 |
245 |
120 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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