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EC number: 939-238-3 | CAS number: -
In a dermal sensitization study according to OECD TG 406 with Stearic acid, esters with methyl α-D-glucoside (100 % a.i., according to producer information), Pirbright white guinea pigs were tested using the method of Magnusson and Kligman. Positive control substance was 2,4 dinitrochlorobenzene.
For intradermal induction a concentration of 5 % was used. The test concentration used for dermal induction (25 %) was non-irritating. However, 7 days after first intradermal induction the test site was pretreated with 10 % sodium laurylsulfat in petrolatum in order to create a local irritation. 24 hours later a 25 % dilution of the test substance was applied and covered by occlusive dressing for 48 hours. The same non-irritating test substance concentration (25 %) was used for challenge procedure.
According to OECD guideline 406 a pretreatment with sodium lauryl sulphate is recommended, if the test substance is not a skin irritant. Thus, it can be assumed that including the pretreatment with the promoter substance sodium lauryl sulphate the induction procedure was sufficient to induce a potential allergic sensitisation reaction and the study is judged as valid.
At challenge no visible changes of the treated skin sites (no erythema and no edema) were observed in test or control animals at any time point.
In this study Stearic acid, esters with methyl α-D-glucoside (a.i. 100 %, according to producer information), is not a dermal sensitizer.
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