Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects up to the limit of water solubility for Desmodesmus subspicatus (OECD 201); read-across

Key value for chemical safety assessment

Additional information

Since no studies investigating the short-term toxicity to algae of Fatty acids, C6-18, 2,2-dimethyl-1,3-propanediyl esters (CAS No. 91031-27-5) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across to the structurally most similar category member 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) was conducted. Further justification is given within the endpoint summary in IUCLID section 6.1 and within the category justification in IUCLID section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID section 13 and the overall summary, all reliable data in the category support the hazard assessment by showing a consistent pattern of results.

The key study conducted with 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) was performed as a limit test according to OECD Guideline 201 (Häner, 2006). The test organism Desmodesmus subspicatus was exposed to the test substance in a static system for 72 hours, at the nominal test concentration of 100 mg/L, prepared as water accommodated fractions (WAF). No significant effects on growth or biomass of algae were observed during the study and the EL50 value was reported to be > 100 mg/L. The NOELR was reported to be ≥100 mg/L.

Based on the available result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C6-18, 2,2-dimethyl-1,3-propanediyl esterswill not exhibit effects on aquatic algae up to the limit of water solubility. As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the polyol esters category support this hazard assessment by showing a consistent pattern of results, i.e no toxic effects up to the limit water solubility.

Categories Display