Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

NOELR (21d) >= 1 mg/L (OECD 211, Daphnia magna); read-across

Key value for chemical safety assessment

Additional information

Since no studies investigating the long-term toxicity to aquatic invertebrates of Fatty acids, C6-18, 2,2-dimethyl-1,3-propanediyl esters (CAS No. 91031-27-5) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the category members Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) and 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) is conducted. Further justification is given within the endpoint summary in IUCLID section 6.1 and within the category justification in IUCLID section 13.

The study conducted with 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) was performed as a limit test according to OECD guideline 211 and GLP (Schlechtriem, 2013). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at a loading rate of 1 mg/L (WAF). No significant effect on reproduction was observed during the study, and the NOELR was determined to be ≥ 1 mg/L.

The key study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed according to OECD Guideline 211 and GLP, in a semi-static system (Parr, 2013). During 21 days, the test organism Daphnia magna was exposed to five test concentrations up to 0.0019 mg/L (measured, TWA). No significant effects on reproduction were observed during the study and the NOEC (21d) was reported to be ≥ 0.0019 mg/L.