Registration Dossier
Registration Dossier
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EC number: 203-528-1 | CAS number: 107-87-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The study guideline was equivlaent to the OECD 401 study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentan-2-one
- EC Number:
- 203-528-1
- EC Name:
- Pentan-2-one
- Cas Number:
- 107-87-9
- Molecular formula:
- C5H10O
- IUPAC Name:
- pentan-2-one
- Reference substance name:
- 2-pentanone
- IUPAC Name:
- 2-pentanone
- Reference substance name:
- Methyl n-propyl ketone
- IUPAC Name:
- Methyl n-propyl ketone
- Test material form:
- other: Liquid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals were given a single oral dose of the test article.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 600 - < 3 200 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- The LD50 of the study was given as 1600-3200 mg/kg.
- Executive summary:
Groups of rats were treated with methyl propyl ketone by oral gavage. The reported LD50 was 1600 -3200 mg/kg.
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