Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-246-6 | CAS number: 1314-87-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Lead-induced convulsions in young infants - A case history and the role of GABA and sodium valproate in the pathogenesis and treatment
- Author:
- M.A. Healy, M. Aslam, P.G. Harrison and N.P. Fernando
- Year:
- 1 984
- Bibliographic source:
- Journal of clinical and hospital pharmacy
Materials and methods
- Study type:
- poisoning incident
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Case report + Lead NMR analysis
- GLP compliance:
- not specified
Method
- Subjects:
- - Number of subjects exposed: 1
- Sex: unknown
- Age: 90 days
- Race: syrian
- Demographic information: arabic countries
- Known diseases: convulsions, encephalopathic oedema - Route of exposure:
- dermal
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
Results and discussion
- Clinical signs:
- Convulsions decreased after appropriated treatment
Any other information on results incl. tables
Some treatments acting on GABAergic neuroinhibitory system did not work, due to a lead/GABA interaction.
Applicant's summary and conclusion
- Conclusions:
- Considering this case report, lead sulfide induces a neurotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
