Registration Dossier
Registration Dossier
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EC number: 203-176-9 | CAS number: 104-12-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
skin sensitisation: Guinea Pig sensitisation test; result: not sensitising
Respiratory sensitisation
Endpoint conclusion
- Additional information:
There are no data on respiratory sensitization available. p-chlorophenylisocyanate is a monoisocyanate. The UK Health and Safety Commission Working Group on the Assessment of Toxic Chemicals, Working Group on Action to Control Chemicals concluded performed an assessment of the potential for isocyanic acid and other monoisocyanates to cause respiratory irritation and sensitization (WATCH Committee Paper WATCH/2008/4, 17 Jun., 2008; http://www.hse.gov.uk/aboutus/meetings/iacs/acts/watch/170608/p4.pdf) and came to the following conclusion: “With the exception of methyl isocyanate, information on the toxicity of the monoisocyanates is sparse. There is no direct evidence that any of the monoisocyanates can cause respiratory sensitisation. … However, this indirect information on the allergenicity and immunoreactivity of the monoisocyanates is very limited, and insufficient to reliably inform on their potential to cause respiratory sensitisation.” A similar conclusion was drawn by the German MAK commission concerning the monoisocyanates in 2009 (MAK- und BAT-Werteliste 2009).
Justification for classification or non-classification
The test substance is not sensitizing to the skin - a classification is not justified.
Due to regulation 67/548/EEC isocyanates have to be classified as respiratory sensitisers with R 42.
According RL 1272/2008/EG (GHS) no classification for respiratory sensitisation is necessary (see discussion).
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