Registration Dossier
Registration Dossier
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EC number: 203-176-9 | CAS number: 104-12-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: In compliance with current guideline, but individual animal data were not shown
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Method: other: see freetext ME
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, no data on purity
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no symptoms or deaths occured over a 14-day observation period
- Clinical signs:
- other: no symptoms or deaths occured over a 14-day observation period
- Gross pathology:
- at the time of sacrifice, a gross necropsy revealed a darkened ring at the base of the cortex of the kidneys.
other internal organs appeared normal - Other findings:
- no data
Any other information on results incl. tables
RS-Freetext:
No symptoms or death occurred during the 14-day observation
period.
Gross necropsy revealed a darkened ring at the base of the
cortex of the kidneys; other internal organs appeared
normal.
Applicant's summary and conclusion
- Executive summary:
method:
Backs of 2 males and 2 females were shaved and abraded by scrubbing.
Compound was applied undiluted to the skin at a dose level of 2000 mg/kg. Animals were observed 14 days for symptoms and mortality.
Gross necropsy was performed with a general inspection of
the digestive tract, liver, kidneys, heart lungs and spleen.result: No symptoms or death occured during the 14-day observation period.
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