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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Published studies in human pregnancy (reliability = Klimisch 2) indicate that low doses of the read-across substance, aspirin (acetylsalicylic acid). is not associated with adverse effects when administered during human pregnancy.

Additional information

Salicylates have been shown to be teratogenic in rats, however, published studies in human pregnancy (reliability = Klimisch 2) indicate that low dose aspirin (acetylsalicylic acid) is not associated with adverse effects when administered during human pregnancy (Koser et al, 2003, CLASP 1995, Kaandorp et al 2009). The doses of aspirin used in the studies ranged from 20 mg to 100 mg daily. Therefore, by read-across, the subsalicylate component of bismuth subsalicylate is not classified for developmental toxicity.