Registration Dossier
Registration Dossier
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EC number: 486-080-1 | CAS number: 924626-15-3
Endpoint summary
Administrative data
Description of key information
Additional information
The log Kow is a useful screening tool for many substances, and it is generally assumed that non-ionised organic substances with a log Kow below 3 (4, GHS) are not significantly bioaccumulative (ECHA, 2008).
In accordance with current ECHA guidance (2008), several current models were used for a screening to estimate a BCF (Bioaccumulation factor) for SymHelios® 1031 using either Kow or the aqueous solubility as input parameters. None of the used models predicted BCFs > 1200 L/Kg ww. In addition, the models most applicable to the considered substance predicted BCF values in the range of 33 to 332 L/kg ww well below the PBT or vPvB criteria according to Annex XIII of REACH regulation (i.e., BCF > 2000 L/kg, > 5000 L/kg, respectively). For detailed information please refer to the attached PBT-Assessment report “section 13-IUCLID.
The bioaccumulation potential is one of the criteria used for the PBT/vPvB assessment. A provisional assessment can be made against screening criteria based on the Kow for substances that are expected to accumulate via passive diffusion such as SymHelios® 1031. Furthermore, no specific uptake mechanism apart from lipophilic partitioning is known or suspected. According to ECHA “Guidance on information requirements and chemical safety assessment / Part C: PBT assessment” (May 2008), the criteria for bioaccumulation (B and vB) are not fulfilled, if the logPow is ≤ 4.5.
For organic substances with a log Kow value below 4.5 it is assumed that the affinity for the lipids of an organism is insufficient to exceed the B criterion, i.e. a BCF value of 2000 L/kg ww.
Furthermore, there is no convincing evidence that SymHelios® 1031 can biomagnify in the food chain (BMF < 1). Therefore, the criteria for “bioaccumulating” and for “very bioaccumulating” are not fulfilled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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