Registration Dossier
Registration Dossier
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EC number: 611-435-6 | CAS number: 56962-04-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 2002
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: Acute dermal toxicity
- Limit test:
- yes
Test material
- Reference substance name:
- 3-bromo-5-chlorophenol
- EC Number:
- 611-435-6
- Cas Number:
- 56962-04-0
- Molecular formula:
- C6H4BrClO
- IUPAC Name:
- 3-bromo-5-chlorophenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Charles River Laboratories, Research Models and Services, Germany GmbH, Sanhofer Weg 7, 97633 Sulzfeld, Germany
Body weight: (at dosing) Males: 208-227 g; Female: 200-219 g
Age: (at dosing) Males: 51 days; Females: 65 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Sesame oil
- Details on dermal exposure:
- Hair on the site of applicatiom was clipped with a hair clipper 24 hrs before administration.
The test item suspension was applied to 8 layers of gauze.
The gauze was covered with plastic sheet. - Duration of exposure:
- 24 hours
- Doses:
- 1 Doses - 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5 male and 5 female
- Details on study design:
- Observation of skin reactions, changes in body weight clinical signs and necropsy were performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: 24h - > 2000 mg/kg; 14 days - > 2000 mg/kg
- Mortality:
- none
- Clinical signs:
- none
- Body weight:
- Males: 208-227 g
Female: 200-219 g - Gross pathology:
- no findings at necopsy
- Other findings:
- no skin reactions
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the present test conditions, a single dermal application of 2000 mg/kg b.w. to rats did not reveal any clinical signs of toxicity. No influence on animal behaviour or premature mortality was noted. The body wight gain was not influenced. No skin reactions were observed at the application site. The macroscopic examination did not reveal any changes.
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