Registration Dossier
Registration Dossier
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EC number: 700-320-7 | CAS number: 18916-17-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
LD50(rat), oral: > 2000 mg/kg b.w. (OECD 423 / EC B.1, GLP); limit test
Skin irritation: not irritant (in vitro“Interleukin-1α”, GLP)
Eye irritation: not irritant ( in vitro “HET-CAM”)
Skin sensitisation: not sensitising (OECD 429 / EC B.42, GLP); LLNA
in vitro: Gene mutation (Bacterial reverse mutation assay / Ames test): S. typhimurium TA 1535, TA 1537, TA 98 and TA 100, TA102 negative with and without metabolic activation; Concentration range in the main test (experiment I: 3, 10, 33, 100, 333, 1000, 2500 and 5000 µg/plate and experiment II: 33, 100, 333, 1000, 2500 and 5000 µg/plate, according to OECD 471.
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