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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-05-26 to 2008-06-10
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Version / remarks:
, 1981
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: ISO13320-1: Particle Size Analysis - Laser Diffraction Methods
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
signed 2004-09-06
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(4-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
EC Number:
700-320-7
Cas Number:
18916-17-1
Molecular formula:
C27H34O14
IUPAC Name:
1-(4-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
Constituent 2
Reference substance name:
1-[4-[[2-O-(6-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihdroxyphenyl]-3(4-hydroxyphenyl)-1-propanone
IUPAC Name:
1-[4-[[2-O-(6-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihdroxyphenyl]-3(4-hydroxyphenyl)-1-propanone
Details on test material:
- Name of test material (as cited in study report): Naringin dihydrochalcone (DHC)
- Substance type: technical product
- Physical state: whitish powder
- Storage condition of test material: 15 – 25 °C, dark, dry, don’t freeze, keep away from strong light and heat
No further details are given.

Results and discussion

Particle sizeopen allclose all
Percentile:
D50
Mean:
10 µm
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Percentile:
D50
Mean:
10 µm
St. dev.:
0.08
Percentile:
D10
Mean:
2.4 µm
St. dev.:
0.04
Percentile:
D90
Mean:
40.2 µm
St. dev.:
0.54
Particle size distribution at different passagesopen allclose all
No.:
#1
Size:
0.02 µm
Distribution:
0 %
No.:
#2
Size:
356 µm
Distribution:
100 %
No.:
#5
Size:
5.6 µm
Distribution:
26 %
No.:
#3
Size:
0.6 µm
Distribution:
2.8 %
No.:
#6
Size:
8.9 µm
Distribution:
44 %
No.:
#7
Size:
12.6 µm
Distribution:
60 %
No.:
#8
Size:
20 µm
Distribution:
76.7 %
No.:
#9
Size:
79.6 µm
Distribution:
95.8 %
No.:
#10
Size:
126.2
Distribution:
97.7 %

Applicant's summary and conclusion

Conclusions:
The average of the median physical particle size D50 is 10 µm.