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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.1100 (Acute Oral Toxicity)
Qualifier:
according to guideline
Guideline:
other: JMAFF, Japanese Test Guidelines
GLP compliance:
yes
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
(3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde
EC Number:
801-656-8
Cas Number:
1416808-92-8
Molecular formula:
C8H9ClO2
IUPAC Name:
(3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Doses:
2000mg/kg (10ml/kg) body weight (only dosed to females).
200mg/kg (10ml/kg) body weight (dosed to males and females).
No. of animals per sex per dose:
3
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
other: mortality
Effect level:
2 000 mg/kg bw
Remarks on result:
other: 2 of the 3 females died.
Sex:
male/female
Dose descriptor:
other: mortality
Effect level:
> 200 mg/kg bw
Remarks on result:
other: None of the 6 animals dosed at 200mg/kg died.
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 - <= 2 000 mg/kg bw
Mortality:
See effect levels above.
Clinical signs:
other: The surviving female dosed at 2000mg/kg body weight showed clinical signs throughout the study period. The animals dosed at 200mg/kg had recovered from the symptoms between days 2 and 4, except for staining of the fur, which was observed throughout the st
Gross pathology:
Macroscopic post mortem examination of the surviving animals at termination did not reveal any abnormalities. Watery fluid in the uterus, found in one female, is related to a stage in the oestrous cycle and is a normal finding.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria