Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 269-214-1 | CAS number: 68201-37-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxicological effects up to the limit of the water solubility of Octadecanoic acid, branched and linear (2.5 mg/L) are expected .
Key value for chemical safety assessment
Additional information
Two studies investigating the short-term toxicity to freshwater fish of Fatty Acids, C16-18 and C-18, unsaturated, branched and linear and Isooctadecanoic acid were used as read across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5 grouping of substance and read across approach for Octadecanoic acid, branched and linear. Firstly, for Fatty acids, C16-18 and C18-unsatd., branched and linear the semi-static short term test with freshwater fish (Leuciscus idus) according to OECD guideline 203 observed no mortality within the tested concentrations. Due to the low water solubility of Fatty acids, C16-18 and C18-unsatd., branched and linear (15 mg/L) the test solutions were prepared as Water Accommodated Fractions (WAF). No mortality up to the limit of the water solubility of the test substance was observed (Sewell, 1994). The LL50 (96h) is > 1000 mg/L and the NOELR ≥ 1000 mg/L. One further study investigating the short-term toxicity to freshwater fish of Isooctadecanoic Acid, CAS No. 30399-84-9, is available and was used as read across. This test with Isooctadecanoic acid was conducted in accordance to a German standard test for the evalulation of water-polluting substances (Bewertung wassergefährdender Stoffe, Bestimmung der akuten Fischtoxozität), which is comparable to DIN 38412 L15 under static test conditions with the freshwater fish Cyprinus carpio (Bogers, 1988). Tween 80 was used as solubiliser in order to obtain a homogenous dispersion of the test substance in water. Furthermore the test duration was only 48 instead of 96 hours. An LC50 of 13.4 mg/L after 48 hours and a NOEC of 5.6 mg/L was determined. One might expect that expect that the LC50 after 96 hours will be lower, however, as the water solubility of the test substance is only 0.24 mg/L, it can be assumed that the LC50 (96 h) will be higher than the water solubility limit of Isooctadecanoic acid 0.24 mg/L.
In conclusion, no toxicological effects up to the limit of the water solubility of Octadecanoic acid, branched and linear (2.5 mg/L) are expected .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
