Registration Dossier
Registration Dossier
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EC number: 931-895-4 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
The main components of the substance “Reaction product of soluble nickel salt, cobalt salt, manganese salt with alkalines” are cobalt dihydroxide, nickel dihydroxide and manganese dihydroxide.
Cobalt and nickel are considered as the main drivers for human health effects. The major and the most hazardous constituents of this intermediate are cobalt dihydroxide and nickel dihydroxide, which vary within different products 1-35% and 30 -90%, respectively. Because of fine particles (IUCLID-section 4.5: particle size), dust emissions might cause exposure through inhalation for workers, and therefore controlled by existing RMMs taken place in production processes and intermediate use under strictly controlled conditions (see section 11 of IUCLID). Because the substance is used as an intermediate, further hazard assessment is deemed unnecessary.
Cobalt dihydroxide and nickel dihydroxide are the main components of the target UVCB-substance, and considered the major drivers for adverse effects based on its properties and relative quantity in the substance. For read-across purpose, data from the constituents (cobalt dihydroxide and nickel dihydroxide) of the target UVCB-substance or the available data from cobalt and nickel compounds which are considered relevant for the target UVCB-substance is used. According to section 1.5, annex XI of regulation (EC) 1907/2006, such studies do not need to be conducted, since adequate data from structurally analogous substances are available. Therefore read-across from these compounds is justified.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
The main components of the substance “Reaction product of soluble nickel salt, cobalt salt, manganese salt with alkalines” are cobalt dihydroxide, nickel dihydroxide and manganese dihydroxide.
Cobalt and nickel are considered as the main drivers for human health effects. The major and the most hazardous constituents of this intermediate are cobalt dihydroxide and nickel dihydroxide, which vary within different products 1-35% and 30 -90%, respectively. Because of intermediate use under strictly controlled conditions in industrial settings, exposure for general population is considered irrelevant (see section 11 of IUCLID), therefore further hazard assessment is deemed unnecessary.
Cobalt dihydroxide and nickel dihydroxide are the main components of the target UVCB-substance, and considered the major drivers for adverse effects based on its properties and relative quantity in the substance. For read-across purpose, data from the constituents (cobalt dihydroxide and nickel dihydroxide) of the target UVCB-substance or the available data from cobalt and nickel compounds which are considered relevant for the target UVCB-substance is used. According to section 1.5, annex XI of regulation (EC) 1907/2006, such studies do not need to be conducted, since adequate data from structurally analogous substances are available. Therefore read-across from these compounds is justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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