(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

Qualifier:

according to

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

GLP compliance:

yes

Type of method:

ring method

Key result

Surface tension:

71.887 mN/m

Temp.:

20 °C

Conc.:

1 000 mg/L

The surface tension was constant during the test. The mean value was therefore calculated from the determinations obtained 30 minutes after the preparation and later. The age of the surface was 30 min to 1 h 20 min. The mean surface tension of the test substance was 71.887 mN/m, standard deviation 0.061, at a temperature of 20.0 °C.

Table 1:          Surface tension of water

tensiometer readings (mN/m)	mean (mN/m)	calculated F
71.3	71.3	1.01986
71.4
71.3

Table 2:          Surface tension of the test substance solution

determination	age of the surface of the test substance solution (h:min)	tensiometer readings (mN/m)	experimental value (mN/m)	surface tension (mN/m)
1	00:30	70.4	71.80	71.82
2	00:45	70.5	71.90	71.93
3	01:00	70.5	71.90	71.93
4	01:10	70.4	71.80	71.82
5	01:20	70.5	71.90	71.93
		mean of determinations 1 to 5		71.887
		SD		0.061

Conclusions:

According to the EC Directive, "TAZOBACTAM ACID" is not surface active because its surface tension is greater than 60 mN/m.

Executive summary:

The surface tension of the test substance was determined with the ring method according to OECD- and EC-methods.

The mean surface tension of the test substance was 71.887 mN/m, standard deviation 0.061, at a temperature of 20.0 °C.

Description of key information

Key study: Test method according to OECD 115. GLP study.The surface tension of the test substance was determined with the ring method. The mean surface tension of the test substance was 71.887 mN/m, standard deviation 0.061, at a temperature of 20.0 °C.

Key value for chemical safety assessment

Surface tension:

71.887

in mN/m at 20°C and concentration in mg/L:

1 000