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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Remarks:
testing lab.
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Trifluoro(tetrahydrofuran)boron
EC Number:
207-325-9
EC Name:
Trifluoro(tetrahydrofuran)boron
Cas Number:
462-34-0
Molecular formula:
C4H8BF3O
IUPAC Name:
trifluoro(oxolan-1-ium-1-yl)boranuide
Details on test material:
Name of the test substance used in the study report: Borfluorid-Tetrahydrofuran
Batch number 5/93

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Animal weight: 150 - 300 g
Individual identification of the rats using cage cards and group identification by tail marking.
The animals were housed in fully air-conditioned rooms with 20 - 24°C for temperature and 30 - 70% for relative humidity. The day/night rhythm was 12 h dark and 12 h light. The rats were singly hold in stainless steel wire mesh cages without beding. A standard diet and tap water were offered ad libitum per day.
The acclimatization period was at least 1 week. The animals were given no feed at least 16 hours before administration; water was available ad libitum.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Doses:
200 mg/kg and 2000 mg/kg
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days (200 mg/kg); 0 days (2000 mg/kg)
- Frequency of observations and weighing: shortly before application, weekly thereafter and at the end of the study.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 - < 2 000 mg/kg bw
Mortality:
200 mg/kg 0/3; 2000 mg/kg 3/3
Clinical signs:
other: 200 mg/kg group: impaired general state and dyspnea. 2000 mg/kg group: poor general state, dyspnoea, apathy, abdominal position, staggering, ataxia, paresis, cyanosis
Gross pathology:
Animals that died: hemorrhage in the mucosa of the stomach and substance discoloration of the contents in the small intestines.
No abnormalities were found in sacrificed animals.

Applicant's summary and conclusion