Registration Dossier
Registration Dossier
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EC number: 269-087-2 | CAS number: 68187-32-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two bioaccumulation studies as-
WoE 2. and WoE 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: WoE 2: Fish and WoE 3: Aquatic organisms
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- WosE 2:
BASIS FOR CALCULATION OF BCF
- Result based on calculated logKow of: -3.69
WoE 3: no data available - Key result
- Type:
- BCF
- Value:
- 3 dimensionless
- Remarks on result:
- other: WoE 2: BCF value of test chemical was estimated using a logKow and a regression-derived equation.
- Key result
- Remarks on result:
- other: WoE 3: Although BCF value of test chemical was not known, but it was reported to be non-bioaccumulative in aquatic organisms.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be 3 dimensionless. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain.
- Executive summary:
Data available for its read across chemicals has been reviewed to determine the bioaccumulation potential of the test chemical. The studies are as mentioned below:
The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of -3.69 and a regression-derived equation. The estimated BCF (bioaccumulation factor) valueof test chemical was evaluated to be 3 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical was considered to be non-accumulative in aquatic organisms.
In an another study, test chemical was reported to be non-bioaccumulative in aquatic organisms.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be 3 dimensionless. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain.
Reference
WoE 2: According to a classification scheme, the BCF value of test chemical suggests the potential for bioconcentration in aquatic organisms is low.
WoE 3: Test chemical was reported to be non-bioaccumulative.
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be 3 dimensionless. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3 dimensionless
Additional information
Data available for its read across chemicals has been reviewed to determine the bioaccumulation potential of the test chemical. The studies are as mentioned below:
The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of -3.69 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was evaluated to be 3 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical was considered to be non-accumulative in aquatic organisms.
In an another study, test chemical was reported to be non-bioaccumulative in aquatic organisms.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be 3 dimensionless. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain.
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