Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review of published data, most of which was produced prior introduction of GLP and OECD testing guiedelines.

Data source

Reference
Reference Type:
review article or handbook
Title:
Concise International Chemical Assessment Document 77, Strontium and Strontium Compounds
Author:
UNEP
Year:
2010
Bibliographic source:
http://www.who.int/ipcs/en/

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Review on all available experimental data on ADME
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Strontium and Strontium compounds
IUPAC Name:
Strontium and Strontium compounds
Constituent 2
Reference substance name:
Strontium chloride
EC Number:
233-971-6
EC Name:
Strontium chloride
Cas Number:
10476-85-4
IUPAC Name:
strontium dichloride
Radiolabelling:
other: 90-Sr or unlabelled material

Test animals

Species:
other: human, rat, dog
Sex:
male/female

Results and discussion

Main ADME resultsopen allclose all
Type:
distribution
Results:
Strontium is incorporated into bone.
Type:
absorption
Results:
Absorption occurs after inhalation and ingestion. Undamaged skin appears to be an effective barrier.
Type:
excretion
Results:
Strontium is excreted in urine and feces.

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Strontium chloride and soluble strontium compounds are absorbed after ingestion and inhalation. Undamaged skin appears to be an effective barrier.
Details on distribution in tissues:
Strontium is transported in the plasma and detected in all body fluids. It is partly incorporated into bone.
Details on excretion:
Excretion occurs both via urine and feces. Elimination from Strontium incorporated into bone is slow.

Applicant's summary and conclusion