Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review of published data, most of which was produced prior introduction of GLP and OECD testing guiedelines.

Data source

Reference
Reference Type:
review article or handbook
Title:
Concise International Chemical Assessment Document 77, Strontium and Strontium Compounds
Author:
UNEP
Year:
2010
Bibliographic source:
http://www.who.int/ipcs/en/

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Review on all available experimental data on ADME
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Strontium and Strontium compounds
IUPAC Name:
Strontium and Strontium compounds
Constituent 2
Reference substance name:
Strontium chloride
EC Number:
233-971-6
EC Name:
Strontium chloride
Cas Number:
10476-85-4
IUPAC Name:
strontium dichloride
Radiolabelling:
other: 90-Sr or unlabelled material

Test animals

Species:
other: human, rat, dog
Sex:
male/female

Results and discussion

Main ADME resultsopen allclose all
Type:
distribution
Results:
Strontium is incorporated into bone.
Type:
absorption
Results:
Absorption occurs after inhalation and ingestion. Undamaged skin appears to be an effective barrier.
Type:
excretion
Results:
Strontium is excreted in urine and feces.

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Strontium chloride and soluble strontium compounds are absorbed after ingestion and inhalation. Undamaged skin appears to be an effective barrier.
Details on distribution in tissues:
Strontium is transported in the plasma and detected in all body fluids. It is partly incorporated into bone.
Details on excretion:
Excretion occurs both via urine and feces. Elimination from Strontium incorporated into bone is slow.

Applicant's summary and conclusion