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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 277-335-6 | CAS number: 73263-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review of published data, most of which was produced prior introduction of GLP and OECD testing guiedelines.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Concise International Chemical Assessment Document 77, Strontium and Strontium Compounds
- Author:
- UNEP
- Year:
- 2 010
- Bibliographic source:
- http://www.who.int/ipcs/en/
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Review on all available experimental data on ADME
- GLP compliance:
- no
Test material
- Reference substance name:
- Strontium and Strontium compounds
- IUPAC Name:
- Strontium and Strontium compounds
- Reference substance name:
- Strontium chloride
- EC Number:
- 233-971-6
- EC Name:
- Strontium chloride
- Cas Number:
- 10476-85-4
- IUPAC Name:
- strontium dichloride
Constituent 1
Constituent 2
- Radiolabelling:
- other: 90-Sr or unlabelled material
Test animals
- Species:
- other: human, rat, dog
- Sex:
- male/female
Results and discussion
Main ADME resultsopen allclose all
- Type:
- distribution
- Results:
- Strontium is incorporated into bone.
- Type:
- absorption
- Results:
- Absorption occurs after inhalation and ingestion. Undamaged skin appears to be an effective barrier.
- Type:
- excretion
- Results:
- Strontium is excreted in urine and feces.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Strontium chloride and soluble strontium compounds are absorbed after ingestion and inhalation. Undamaged skin appears to be an effective barrier.
- Details on distribution in tissues:
- Strontium is transported in the plasma and detected in all body fluids. It is partly incorporated into bone.
- Details on excretion:
- Excretion occurs both via urine and feces. Elimination from Strontium incorporated into bone is slow.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.