Sorbitan monostearate, ethoxylated

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of various test chemical

Justification for type of information:

Experimental data of various test chemical

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE was prepared for the determination of toxicity of test chemical on aquatic algae:

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: Green algae

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Reference substance (positive control):

not specified

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 56 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Growth rate and AUG

Remarks on result:

other: 1st study

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

150 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: 2nd study

Validity criteria fulfilled:

no

Conclusions:

1: Based on the growth rate inhibition of green algae and area under the growth rate, the EC50 was observed at > 56 mg/l and the NOEC value was determine at 46 mg/l.
2: Based on the growth rate inhibition and area under the growth of green algae the EC50 was observed at 150 mg/l and 110 mg/l. Whereas No effect were observed at 31 mg/l.
Thus based on the effects observation on algae, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Executive summary:

Summarized result for the toxicity of test chemical by observing the effect on the growth rate inhibition of aquatic algae was studied. The studies are reviewed and mention as below:

 

Short term toxicity study of test chemical to algal growth inhibition test was carried out for 72hrs. Test conducted according to the OECD Guideline 201 (Alga, Growth Inhibition Test). Test conducted under the static system. Based on the growth rate inhibition of green algae and area under the growth rate, the EC50 was observed at > 56 mg/l and the NOEC value was determine at 46 mg/l. As the chemical was readily biodegradable in water, thus chemical consider to be nontoxic and not classified as per the CLP classification criteria.

 

Similar short term toxicity study to algal growth inhibition test was carried out for 72hrs. Test conducted according to the OECD Guideline 201 (Alga, Growth Inhibition Test). Test conducted under the static system for 72 hrs. Based on the growth rate inhibition and area under the growth of green algae the EC50 was observed at 150 mg/l and 110 mg/l. Whereas No effect were observed at 31 mg/l. Thus on the basis of EC50 value, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

 

Thus based on the effects observation on algae, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Description of key information

1: Based on the growth rate inhibition of green algae and area under the growth rate, the EC50 was observed at > 56 mg/l and the NOEC value was determine at 46 mg/l.

2: Based on the growth rate inhibition and area under the growth of green algae the EC50 was observed at 150 mg/l and 110 mg/l. Whereas No effect were observed at 31 mg/l.

Thus based on the effects observation on algae, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Key value for chemical safety assessment

EC50 for freshwater algae:

150 mg/L

Additional information

Summarized result for the toxicity of test chemical and read across chemicals, studied has been reviewed by observing the effect on the growth rate inhibition of aquatic algae. The studies are reviewed and mention as below:

 

Short term toxicity study of test chemical to algal growth inhibition test was carried out for 72hrs. Test conducted according to the OECD Guideline 201 (Alga, Growth Inhibition Test). Test conducted under the static system. Based on the growth rate inhibition of green algae and area under the growth rate, the EC50 was observed at > 56 mg/l and the NOEC value was determine at 46 mg/l. As the chemical was readily biodegradable in water, thus chemical consider to be nontoxic and not classified as per the CLP classification criteria.

 

Similar short term toxicity study to algal growth inhibition test was carried out for 72hrs. Test conducted according to the OECD Guideline 201 (Alga, Growth Inhibition Test). Test conducted under the static system for 72 hrs. Based on the growth rate inhibition and area under the growth of green algae the EC50 was observed at 150 mg/l and 110 mg/l. Whereas No effect were observed at 31 mg/l. Thus on the basis of EC50 value, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

 

Thus based on the effects observation on algae, chemical consider to be nontoxic and not classified as per the CLP classification criteria.