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Long-term toxicity to fish

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Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of test chemicals
Justification for type of information:
Experimental data of various test chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two long term toxicity study of fish for the test chemical:
1. and 2. Long-term toxicity to fish of test material
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
static
Water media type:
freshwater
Total exposure duration:
14 d
Reference substance (positive control):
no
Key result
Duration:
14 d
Dose descriptor:
other: LC50
Effect conc.:
> 50 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Other details not known
Duration:
14 d
Dose descriptor:
NOEC
Effect conc.:
> 5 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
no
Conclusions:
The test chemical is not likely to be toxic to fish atleast in the concentration range of 50 mg/l
Executive summary:

Data available for the test chemicals has been reviewed to determine the long term toxicity of fish .The studies are as mentioned below:

Long term toxicity study was evaluated for test material according to OECD Guideline 204 (Fish, Prolonged Toxicity Test) for 14 days. The effect concentration for test material after 14 days study on fish was observed to be > 50 mg/l. Thus, it can be concluded that effect concetration value is greater than 50 mg/ L. Thus, comparing this value with the criteria of CLP regulation, test material cannot be classified for long term toxicity for fish.

First study was supported by the second. The long term toxicity of test material was evaluted for fish according to OECD 204 prolong toxicity to fish for 14 days. Based on the mortality of fish by chemical, the no observed effect concentration (NOEC) and (EC50) was observed to be > 5 mg/l. On the basis of above effect concentrations, chemical can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

Thus, based on the above summarised studies, it can be concluded that effect concetration value is greater than 50 mg/ L. Thus, comparing this value with the criteria of CLP regulation, test chemical cannot be classified for long term toxicity for fish .

Description of key information

The test chemical is not likely to be toxic to fish atleast in the concentration range of 50 mg/l

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
5 mg/L

Additional information

Data available for the test chemicals has been reviewed to determine the long term toxicity of fish .The studies are as mentioned below:

Long term toxicity study was evaluated for test material according to OECD Guideline 204 (Fish, Prolonged Toxicity Test) for 14 days. The effect concentration for test material after 14 days study on fish was observed to be > 50 mg/l. Thus, it can be concluded that effect concetration value is greater than 50 mg/ L. Thus, comparing this value with the criteria of CLP regulation, test material cannot be classified for long term toxicity for fish.

First study was supported by the second.The long term toxicity of test material was evaluted for fish according to OECD 204 prolong toxicity to fish for 14 days. Based on the mortality of fish by chemical, the no observed effect concentration (NOEC) and (EC50) was observed to be > 5 mg/l. On the basis of above effect concentrations, chemical can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

Thus, based on the above summarised studies, it can be concluded that effect concetration value is greater than 50 mg/ L. Thus, comparing this value with the criteria of CLP regulation, test chemical cannot be classified for long term toxicity for fish .