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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented publication giving sufficient detail for evaluation.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Urinary silicon excretion by rats following oral administration of silicon compounds.
Author:
Benke, G. M. and Osborn, T. W.
Year:
1979
Bibliographic source:
Fd. Cosmet. Toxicol. 17, 123-127.
Reference Type:
secondary source
Title:
Soluble Silicates. CAS No. 1344-09-8, 6834-92-0, 10213-79-3, 13517-24-3 and 1312-76-1.
Author:
OECD SIDS
Year:
2004
Bibliographic source:
SIDS Initial Assessment Report for SIAM 18 Paris, France 20-23 April, 2004

Materials and methods

Objective of study:
excretion
Principles of method if other than guideline:
Measurement of urinary excretion after single oral application
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
sodium silicate of molar ratio 2.4
Radiolabelling:
no

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses / concentrations
Remarks:
Doses / Concentrations:
two trials with 40 and 1000 mg/kg, respectively

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
At the 40 mg/kg level 18.9% of administered silicate was excreted in the urine, elevated levels of Si in the urine were observed only in the first 24 hrs after oral dosing.  At the 1000 mg/kg level 2.8% of the total administered silicate was excreted in the urine. The urinary excretion half-life for ingested sodium silicate was calculated to be 24 hours. The excretion rate was independent of the doses applied indicating that  the limiting factor is the rate of production of soluble or absorbable  silicon in the gastrointestinal tract.

Applicant's summary and conclusion