Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information
No information available.
Effect on fertility: via oral route
Endpoint conclusion:
no study available
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no adverse effect observed
Additional information

Trimethylaluminium is classified as Pyr. Liquid 1, Water React. Flam. Gas 1 and Skin Corr. 1B. Therefore, the substance ignites upon exposure to air, reacts violently with water and causes severe burns to the skin and eyes. Consequently, it is not technically feasible to conduct toxicological studies with this substance.

Trimethylaluminium reacts spontaneously with water to produce aluminium hydroxide and methane or methanol and reacts spontaneously with air; the products of complete combustion being aluminium oxide, carbon dioxide and water. Therefore, the toxicological effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of long-term exposure to trimethylaluminium.

Aluminium oxide and aluminium hydroxide are not classified for human health effects. These substances are of low acute oral toxicity with a very low oral bioavailability. Due to their insolubility in water, it is predicted that aluminium oxide and aluminium hydroxide will not be absorbed through the skin. Following inhalation exposure to aluminium oxide and aluminium hydroxide, the available data indicate that transfer of aluminium to the systemic circulation is low. There is no conclusive evidence that exposure to aluminium oxide or aluminium hydroxide leads to skin, eye or respiratory irritation effects. These aluminium salts also appear to have low sensitising potential. There are also no data to suggest that aluminium oxide and aluminium hydroxide are mutagenic or carcinogenic or that they have adverse reproductive/developmental effects.


Short description of key information:
Trimethylaluminium is classified as Pyr. Liquid 1, Water React. Flam. Gas 1 and Skin Corr. 1B. Therefore, the substance ignites upon exposure to air, reacts violently with water and causes severe burns to the skin and eyes. Consequently, it is not technically feasible to conduct toxicological studies with this substance.

Effects on developmental toxicity

Description of key information
Trimethylaluminium is classified as Pyr. Liquid 1, Water React. Flam. Gas 1 and Skin Corr. 1B. Therefore, the substance ignites upon exposure to air, reacts violently with water and causes severe burns to the skin and eyes. Consequently, it is not technically feasible to conduct toxicological studies with this substance.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

See Discussion under effects on fertility.

Justification for classification or non-classification

The substance is not classified for reproductive/developmental toxicity as it rapidly converts to aluminium oxide or aluminium hydroxide; both these substances are not classified.