Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - workers

Toxicological testing is not applicable as the substance reacts spontaneously with water to produce aluminium hydroxide and methane or methanol and also reacts spontaneously with air; the products of complete combustion being aluminium oxide, carbon dioxide and water. Therefore it is not possible to calculate systemic DNELs for the substance. The toxicological effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of long-term exposure to trimethylaluminium. Aluminium oxide and aluminium hydroxide are of low toxicity, are poorly absorbed by the oral, inhalation and dermal routes and are not classified for human health effects.

The test substance is classified as a Skin Corr. 1B. No dose response data are available therefore it is not possible to derive local DNEL values. Medium hazard is therefore assigned for local effects on the skin, eyes and respiratory tract in accordance with ECHA CSA Guidance part E Table E 3 -1.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - General Population

Toxicological testing is not applicable as the substance reacts spontaneously with water to produce aluminium hydroxide and methane or methanol and also reacts spontaneously with air; the products of complete combustion being aluminium oxide, carbon dioxide and water. Therefore it is not possible to calculate systemic DNELs for the substance. The toxicological effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of long-term exposure to trimethylaluminium. Aluminium oxide and aluminium hydroxide are of low toxicity, are poorly absorbed by the oral, inhalation and dermal routes and are not classified for human health effects.

The test substance is classified as a Skin Corr. 1B. No dose response data are available therefore it is not possible to derive local DNEL values. Medium hazard is therefore assigned for local effects on the skin, eyes and respiratory tract in accordance with ECHA CSA Guidance part E Table E 3 -1.