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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-diphenylpropane-1,3-dione
EC Number:
204-398-9
EC Name:
1,3-diphenylpropane-1,3-dione
Cas Number:
120-46-7
Molecular formula:
C15H12O2
IUPAC Name:
1,3-diphenylpropane-1,3-dione
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

In vivo test system

Test animals

Species:
mouse
Strain:
CBA

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
No. of animals per dose:
5

Results and discussion

In vivo (LLNA)

Results
Parameter:
SI
Remarks on result:
other: see Remark
Remarks:
Each of the three tested concentrations of the test item exceeded the stimulation index of3. The stimulation index at a concentration of 6.25% was 3.3 The stimulation index at a concentration of 12.5% was 3.8 The stimulation index at a concentration of 25% was 3.6 The mean ear thickness on day 1 day 3 day 6 for the 6.25% test group was 0.18 mm 0.18 mm 0.18 mm for the 12.5% test group was 0.18 mm 0.19 mm 0.19 mm for the 25% test group was 0.18 mm 0.18 mm 0.19 mm for the negative control group was 0.18 mm 0.18 mm 0.18 mm

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU