1,3-diphenylpropane-1,3-dione

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vivo (LLNA)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)

GLP compliance:

yes (incl. QA statement)

Type of study:

mouse local lymph node assay (LLNA)

Species:

mouse

Strain:

CBA

Vehicle:

acetone/olive oil (4:1 v/v)

No. of animals per dose:

5

Parameter:

SI

Remarks on result:

other: see Remark

Remarks:

Each of the three tested concentrations of the test item exceeded the stimulation index of3. The stimulation index at a concentration of 6.25% was 3.3 The stimulation index at a concentration of 12.5% was 3.8 The stimulation index at a concentration of 25% was 3.6 The mean ear thickness on day 1 day 3 day 6 for the 6.25% test group was 0.18 mm 0.18 mm 0.18 mm for the 12.5% test group was 0.18 mm 0.19 mm 0.19 mm for the 25% test group was 0.18 mm 0.18 mm 0.19 mm for the negative control group was 0.18 mm 0.18 mm 0.18 mm

Interpretation of results:

sensitising

Remarks:

Migrated information Criteria used for interpretation of results: EU

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)