Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 411-700-4 | CAS number: 140921-24-0 HÄRTER VERSUCHSPRODUKT LS 2959E; HÄRTER VP LS 2959E
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1992-07-14 to 1992-08-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- GLP study, but no internationally accepted guideline followed
- Principles of method if other than guideline:
- internal method: 2011-0340301-92D, SFC method
- GLP compliance:
- yes
- Key result
- Medium:
- other: fat simulative medium HB 307 (NATEC)
- Remarks on result:
- other: 138.5 g per 1000 g fat
- Test substance stable:
- not determined
- Details on results:
- The fat solubility was determined using SFC method and an internal standard (peak area analysis).
- Conclusions:
- The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
- Executive summary:
The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
Reference
Starting from under-saturation:
- 135.1 g per 1000 g fat (1 h at 30 °C)
- 144.2 g per 1000 g fat (3 h at 37 °C)
- 142.9 g per 1000 g fat (1 h at 30 °C)
- 135.1 g per 1000 g fat (24 h at 37 °C)
Starting from over-saturation:
- 141.6 g per 1000 g fat (1 h at 50 °C)
- 140.3 g per 1000 g fat (3 h at 37 °C)
- 135.1 g per 1000 g fat (1 h at 50 °C)
- 133.8 g per 1000 g fat (24 h at 37 °C)
Mean value: 138.5 g/ 1000 g fat (standard deviation: 4.2)
- Other: The system fat/test item is a system showing partial miscibility. At the mixing ration fat : test item = 1:1 and 1:10 (wt%) a complete miscibility was observed (in pre-tests). At the mixing ration fat : test item = 10:2 (wt%) two phases coexist. In this system the test item is in the fat phase having a concentration of 178 g/1000 g fat and a solubility of 138.5 g/1000g fat. This system (fat in excess) is therefore a system with a miscibility gap.
Description of key information
The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 13 850
- At the temperature of:
- 20 °C
Additional information
The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
