Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-945-6 | CAS number: 53037-34-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 7, 2012 - August 16, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Remarks on result:
- other: The test item probably is miscible with water in any rate.
- Details on results:
- The test item was miscible with distilled water in a ratio of 1:1 (1kg in 1 L of water), giving at 20 ºC 556.5 g/L of solution which was 257.1 g of dry substance/L and a TOC value of 94.5 g/L. It was concluded that the test item probably is miscible with water in any rate.
- Conclusions:
- It was concluded that the test item probably is miscible with water in any rate.
- Executive summary:
The determination of test item solubility in water using shake flask method was carried out according to the OECD 105 Guideline and EEC A.6 Method (Shake flask method). It was technically infeasible to obtain the analytical standards of the solid components for HPLC analysis and therefore, a non-discriminating method (TOC) was used in order to quantify the total amount of material solubilised. The preliminary test revealed that the water solubility was greater than 1000 g of test item in one liter of water. Afterwards, six water solutions of various of test item content (as weighed 46.2% water solution i.e. the loading) were prepared and the pH and the TOC values of these homogenous, transparent solutions (stable solution for one day for a concentration of 1000 mg/l) were measured. The test item was miscible with distilled water in a ratio of 1:1 (1kg in 1 L of water), giving at 20 ºC 556.5 g/L of solution which was 257.1 g of dry substance/L and a TOC value of 94.5 g/L. It was concluded that the test item probably is miscible with water in any rate.
Reference
Table 1. Results of the preliminary test
Result |
0.1g in x ml of distilled water |
Miscibility (+/-) |
+ |
Approximate miscibility, [g/L] |
> 1000 |
Table 2. TOC and pH values of some test item homogenous, transparent water solutions before the solid phase formation.
NOPCOTE 1661 content, as weighed (i.e. the loading) g/L of water |
0 |
2 |
3 |
4 |
10 |
1000 |
1280 |
Measured TOC after 10 min shaking, g/L of solution |
|
0.39 |
0.56 |
0.73 |
1.81 |
94.50 |
129.28 |
Final pH |
5.6 |
5.04 |
4.91 |
4.36 |
4.03 |
3.30 |
3.11 |
Form after 50 days from dissolving |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
Where:
TOC – Total Organic Carbon,
(+) complete miscibility, transparent
Description of key information
Key study: Test method OECD 105. GLP study. It was concluded that the test item probably is miscible with water in any rate.
Key value for chemical safety assessment
- Water solubility:
- 94.5 g/L
- at the temperature of:
- 20 °C
Additional information
Key study: The determination of test item solubility in water using shake flask method was carried out according to the OECD 105 Guideline and EEC A.6 Method (Shake flask method). It was technically infeasible to obtain the analytical standards of the solid components for HPLC analysis and therefore, a non-discriminating method (TOC) was used in order to quantify the total amount of material solubilised. The test item was miscible with distilled water in a ratio of 1:1 (1kg in 1 L of water), giving at 20 ºC 556.5 g/L of solution which was 257.1 g of dry substance/L and a TOC value of 94.5 g/L. It was concluded that the test item probably is miscible with water in any rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
