Registration Dossier
Registration Dossier
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EC number: 250-465-0 | CAS number: 31098-20-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 5 mg/L (nominal, toxicity control of an OECD 301D)
Key value for chemical safety assessment
Additional information
Since no studies on the toxicity to aquatic microorganisms are available for sulfopropyl acrylate (SPA), a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2014b).
A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on [oxygen demand (BOD/ThOD) or CO2 evolution (CO2/ThCO2)] occurred within 14 days (OECD guideline 301). For sulfopropyl acrylate (SPA) a biodegradation test according to OECD guideline 301 D is available (Mead, 2001). The test includes a toxicity control, which contains 5 mg/L of sulfopropyl acrylate and 1.5 mg/L of the reference material (i.e. sodium benzoate). The toxicity control attained 27 % degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control. The test item concentration of 5 mg/L is used as NOEC.
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