Registration Dossier
Registration Dossier
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EC number: 700-456-7 | CAS number: 1333490-26-8
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 16 June 2009- 9 September 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a: Endpoint Specific Guidance, May 2008
- GLP compliance:
- not specified
- Type of method:
- other: Differential Scanning Calorimeter
Test material
- Reference substance name:
- (2E)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-({4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)prop-2-enamide; propan-2-ol
- EC Number:
- 700-456-7
- Cas Number:
- 1333490-26-8
- Molecular formula:
- C26H31Cl2N5O4 · 1/2(C3H8O1)
- IUPAC Name:
- (2E)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-({4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)prop-2-enamide; propan-2-ol
- Details on test material:
- Molecular weight: 548.47
Batch: 09-002
Purity: >92% (Contains 6.5% isopropanol as a hemi-solvate
Appearance: Yellowish solid
Constituent 1
Results and discussion
Melting / freezing pointopen allclose all
- Melting / freezing pt.:
- ca. 167 °C
- Remarks on result:
- other: DSC trace: Two sharp endothermic transitions were observed.
- Melting / freezing pt.:
- ca. 117 °C
- Remarks on result:
- other: DSC trace: Two sharp endothermic transitions were observed, this one is attributed to the loss of isopropanol from the hemi-solvate
- Melting / freezing pt.:
- >= 167.5 - <= 168.9 °C
- Remarks on result:
- other: After the lost of isopropanol
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
