Naphthalenesulfonic acid, di-C9-rich C8-10-branched alkyl derivs., barium salts

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Ten (10) Wistar rats were exposed to a high concentration (21 mg/L) for 1 hour and no mortality or adverse effects were observed.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Guideline:

other: Acute Inhalation Study , FHSLA, CFR, Title 21.

Deviations:

not specified

GLP compliance:

no

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

barium bis(di C8-C10, branched, C9 rich, alkylnaphthalenesulphonate)

EC Number:

939-718-2

Cas Number:

1474044-80-8

Molecular formula:

C28H44O3S.1/2Ba

IUPAC Name:

barium bis(di C8-C10, branched, C9 rich, alkylnaphthalenesulphonate)

Test material form:

other: as solution in light paraffinic and naphthenic petroleum distillates

Details on test material:

A brownish viscous I iquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

5 male and 5 female rats exposed for 1 hour to a limit dose.

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

Rats were exposed to an aerosol of the test material in an inhalation chamber for one hour. Spray was introduced into
the chamber via a nebul izer and directed away from the animals. The chamber was saturated with 21 mg/liter of the test material.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

>= 1 h

Concentrations:

21 mg/L

No. of animals per sex per dose:

5 male
5 female

Control animals:

no

Statistics:

No mortality, none required.

Results and discussion

Preliminary study:

LC50 greater than 21 mg/L

Mortality:

None

Clinical signs:

other: No untoward effects observed.

Body weight:

See results table.

Applicant's summary and conclusion

Interpretation of results:

relatively harmless

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Exposure to an aerosol of 21 mg/L that results in no mortality or adverse effects demonstrates that the test substance is relatively harmless.

Executive summary:

Acute Inhalation Study conducted with the test susbtance according to FHSLA, CFR, Title 21. A group of five male and five female Wistar rats were exposed to an aerosol of the test material in an inhalation chamber for one hour. The spray was introduced into the chamber via a nebulizer and directed away from the animals. The chamber was saturated with 21 mg/liter of the test material. No mortality or adverse effects were observed. The 1 hour LC50 > 21 mg/L.