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EC number: 412-300-2 | CAS number: 139504-68-0 AMBER CORE
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A key study evaluating the long-term toxicity of Amber Core (P-#620) to aquatic invertebrates (Daphnia magna) is available. The 21d-NOEC, based on immobilisation and reproduction, was determined to be 1.4 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.4 mg/L
Additional information
One key study according to the OECD Guideline 202 part II with GLP standards is available on the aquatic invertebrates (Daphnia magna). This study was performed to assess the prolonged toxicity of Amber Core (P-#620) to Daphnia magna. For this, groups of forty 1st instar Daphnia were exposed for 21 days to a range of concentrations of Amber Core (P-#620) dispersed in water. Daily records were maintained for the mortality rate and general condition of the parental Daphnia. The numbers of live and dead offspring plus discarded unhatched eggs were recorded three times per week on renewal of the test media.
The 21d-EC50 and the 21d-NOEC, based on immobilisation, for the parental Daphnia generation (P1) were 2.4 mg/L (95% confidence limits: 1.9 - 3.0 mg/L) and 1.4 mg/L, respectively.
The 21d-EC50 and the 21d-NOEC, based on reproduction were > 1.4 mg/L and 1.4 mg/L, respectively.
All calculations and estimations are expressed in terms of geometric mean measured concentration. Measured concentrations ranged from 74 - 137% of nominal for fresh media and 51 - 94% of nominal for expired media (average 83%).
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