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EC number: 237-167-6 | CAS number: 13676-91-0
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Acute Toxicity: dermal
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13-13-2001/3-01-2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(2-Chloro-benzoylamino)-4(phenylthio)anthraquinone
- IUPAC Name:
- 1-(2-Chloro-benzoylamino)-4(phenylthio)anthraquinone
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: HanBrl:WIST (SPF)
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- polyethylene glycol
- Duration of exposure:
- 24 h
- Doses:
- The test item 2000 mg/kg dose was diluted in the vehicle at a concentration of 0.5 g/mL and administered at as a volume of 4 mL/kg.
- No. of animals per sex per dose:
- 5 females and 5 males
- Control animals:
- not required
- Details on study design:
- - Mortality/ Viability: Daily during acclimatization and twice daily during days 1-15.
- Body weights: On test days 1 (pre-administration), 8 and 15.
- Clinical signs: Daily during acclimatization and at least four times on test day 1 after the test item administration. Once daily during days 2-15. All abnormalities were recorded.
- Necropsy of survivors performed: yes - Statistics:
- No statistical analysis was used.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred throughout the study.
- Clinical signs:
- other: Red skin and test item residuals were evident in all animals from test day 2 to days 7 or 11. Slight scales on the back were observed in wo males and two females from test day 8 until test day 11.
- Gross pathology:
- No macroscopic findings were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The median lethal dose of FAT 41034/A after single dermal administration to rats of both sexes, observed over a period of 14 days was greater than 2000 mg/kg bw.
- Executive summary:
A group of five male and five female HanBrl: WIST rats were treated with FAT 41'034/A at 2000 mg/kg by dermal application. The test item was diluted in vehicle (PEG 300) at a concentration of 0.5 g/mL and administered at a volume of 4 mL/kg. The animals were examined for clinical signs four times during test day1 and once daily during the test days 2 -15. Mortality/viability was recorded together with the clinical signs at the same time intervals on the test day1. During the test days 2 -15 it was recorded two times a day. BW were recorded on day 1 prior to administration and on days 8 and 15. All animals were necropsied and examined macroscopically. No deaths occurred throughout the study. Red skin and test item residuals were evident in all animals from test day 2 to days 7 or 11. Slight scales on the back were observed in two males and two feamles from test day 8 until test day 11. The bw of the animals were within the range commonly recorded for this strain and age. No macroscopic findings were observed at necropsy. As a conclusion, the median lethal dose of FAT 41034/A after single dermal administration to rats of both sexes, observed over a period of 14 days was greater than 2000 mg/kg bw.
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