Lanthanum(3+) acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Well documented, scientifically sound study with methods similar to OECD 401 with the following deviations: The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided

Data source

Reference

Reference Type:

publication

Title:

Acute Toxicity of Zirconium, Columbium, Strontium, Lanthanum, Cesium, Tantalum, and Yttrium

Author:

Cochran KW, Doull J, Mazur M, DuBois KP

Year:

1950

Bibliographic source:

Industrial Hygiene and Occupational Medicine 1: 637-650,

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lanthanum(3+) acetate

EC Number:

213-034-8

EC Name:

Lanthanum(3+) acetate

Cas Number:

917-70-4

Molecular formula:

C2H4O2.1/3La

IUPAC Name:

lanthanum(3+) triacetate

Details on test material:

- Name of test material (as cited in study report): Lanthanum acetate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: adult
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
Animals were maintained in air conditioned rooms.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 50% suspension

Doses:

The suspension was given in single doses by stomach tube. No further information on doses provided.

No. of animals per sex per dose:

32 rats in total

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: All animals were observed for 10 days. An initial group of animals receiving the test substance were kept for 30 days to verify that if any significant mortality occurred after the tenth day.
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data

Statistics:

The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

10 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: i.e. 4400 mg La/kg bw

Mortality:

No further details reported. No sex differences were noted.

Clinical signs:

other: No further details reported except that lanthanum acetate was found to be the least toxic of several lanthanum compounds tested (lanthanum chloride, lanthanum ammonium nitrate, lanthanum nitrate, lanthanum oxide and lanthanum sulfate.

Gross pathology:

No data

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The oral LD50 was calculated to be 10000 mg compound/kg bw (i.e. 4400 mg La/kg bw)