Registration Dossier

Administrative data

Description of key information

The test substance Decyloxirane was irritating to the skin but not irritating to the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation / corrosion

The skin irritation potential of the test substance was evaluated in a study according to OECD Test Guideline 404 under GLP. The undiluted test substance was applied unchanged under occlusive conditions for 4 hours to the shaved skin of three Mol:Russian rabbits, which were observed for 21 days post application. Over the first three days, clear erythema and oedema were observed in all rabbits, which reversed fully within 21 days. The test substance was considered to be irritating to the skin.

 

Eye irritation

The eye irritation potential of the test substance was evaluated in a study according to OECD Test Guideline 405 under GLP conditions. The amount of 0.1 mL of the undiluted substance was applied unchanged for 24 hours to the eyes of three Mol:russian rabbits, which were observed for 7 days post application. Over the first three days minimal effects on the conjunctiva were observed which did fully reverse within 3 days. The test substance was not considered to be irritating to the eyes.


Justification for selection of skin irritation / corrosion endpoint:
Only study available

Justification for selection of eye irritation endpoint:
Only study available

Effects on skin irritation/corrosion: irritating

Justification for classification or non-classification

Based on the irritating skin effects observed the test substance has to be classified as Skin Irrit. 2: H315: Causes skin irritation in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.

 

As no eye irritating effects were observed, classification for eye irritation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.