Registration Dossier
Registration Dossier
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EC number: 230-786-2 | CAS number: 7320-37-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In the absence of experimental data, for the oral, dermal and inhalatory route, the default absorption values from the REACH guidance (Chapter 8, R.8.4.2) are used for DNEL derivation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Since no toxicokinetic studies are available for the test substance the following assessment is based on the available physicochemical properties and results from other toxicological studies.
The substance is a colorless liquid with a molecular weight of 240.4 g/mol. The log Pow is >5.7 and the water solubility is <0.05 mg/L at 20°C.
Gastrointestinal absorption: Any lipophilic compound may be taken up by micellular solubilisation but this mechanism may be of particular importance for highly lipophilic compounds (Log P >4), particularly those that are poorly soluble in water (≤ 1 mg/L) that would otherwise be poorly absorbed. The low molecular weight ensures that this transport is possible. However, in the oral repeated dose study no treatment related effects were observed up to the highest dose tested (750 mg/kg bw/day). In conclusion, the test substance may not be readily absorbed by the gastrointestinal tract.
Dermal absorption: The substance must be sufficiently soluble in water to partition from the stratum corneum into the epidermis. As the water solubility is below 1 mg/L, dermal uptake is likely to be low. Additionally, a log P of >4 indicates that the rate of penetration may be limited to the epidermis, but uptake into the stratum corneum will be high. A skin irritation study showed that the substance is irritating to the skin, which may enhance the penetration to the skin. However, in a dermal acute toxicity study no systemic effects were observed. Therefore it is assumed that the substance may not be readily absorbed.
Respiratory absorption: No acute or repeated dose information is available. Liquids would readily dissolve into the mucus lining of the respiratory tract. Any lipophilic compound may be taken up by micellular solubilisation but this mechanism may be of particular importance for highly lipophilic compounds (Log P >4), particularly those that are poorly soluble in water (≤ 1 mg/L). No conclusion can be drawn on absorption potential of the test substance via inhalation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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