Registration Dossier
Registration Dossier
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EC number: 257-288-8 | CAS number: 51566-62-2
Endpoint summary
Administrative data
Description of key information
The substance is considered to be slightly irritating to the skin and not irritating to the eye.
Key value for chemical safety assessment
Additional information
Skin Irritation:
In the chosen key study for skin irritation, performed similar to OECD guideline 404, 3 Vienna white rabbits were exposed to 0.5 mL undiluted 3,7-dimethyloct-6-enenitrile for 4 hours under occlusive conditions (BASF 1982). No edema was observed at any time-point. The average erythema score of the 24, 48, and 72 hours time points was 0.33, 0.67 and 0.33 for each animal respectively. These observations were fully reversible within the observation time (8 days).
Irritation was evaluated during an acute dermal LD50 study on 10 rabbits, in which 5000 mg/kg bw of the 3,7-dimethyloct-6-enenitrile was tested (Moreno 1977). Mild redness in all animals, mild edema in 7 of the 10 animals and moderate edema in 2 of the 10 animals was observed.
Overall, 3,7-dimethyloct-6-enenitrile has only a slight skin irritation potential.
Eye Irritation:
In the chosen key study for eye irritation according to OECD guideline 405, 3 Vienna White rabbits were exposed for 8 days to 0.1 mL undiluted 3,7-dimethyloct-6-enenitrile, which was applied to the conjunctival sac of the right eyelid (BASF 1982). Mean Cornea and iris score were 0 at all time points investigated. The average score of the 24, 48, and 72 hour time points were 1 for conjunctivae and and 0 for chemosis for each animal, respectively. Although observations in conjunctivae were not fully reversible within the observation time (8 days), a reversibility at later timepoints is to be expected based on the mild findings observed.
Overall, 3,7-dimethyloct-6-enenitrile has only a slight eye irritation potential.
Justification for classification or non-classification
The present data on skin and eye irritation do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
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