Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP compliant, non guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A dermal LD50 study was determined in 10 rabbits, exposed to 5000 mg/kg of the test material.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyloct-6-enenitrile
EC Number:
257-288-8
EC Name:
3,7-dimethyloct-6-enenitrile
Cas Number:
51566-62-2
Molecular formula:
C10H17N
IUPAC Name:
3,7-dimethyloct-6-enenitrile
Details on test material:
- Name of test material (as cited in study report): Citronellyl Nitrile ; 77-87 (no further data)

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
A dermal LD50 study was conducted on 10 rabbits, using 5000 mg/kg of the test material. The animals were observed for 14 days for mortality and signs. A necropsy was conducted on both the animals that died and on the survivors after day 14. No further details were provided.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
0/10 animals
Clinical signs:
Mild redness in 10/10 animals and mild to moderate edema in 9/10 animals. No furhter clinical signs observed.
Body weight:
no data
Gross pathology:
Fecal matter anogenitally (2 animals), Kidneys: pocked (1 animal), mottled (2 animals), Spleen: Blue-grey sections (1 animal). In six animals no abnormalities were observed.

Applicant's summary and conclusion