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Diss Factsheets
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EC number: 257-288-8 | CAS number: 51566-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, non guideline study, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The methods described by Hagan served as a guide. (E.C. Hagan, "Acute Toxicity", Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics (The Association of Food and Drug Officials of the United States, 1975), pp. 17-25
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,7-dimethyloct-6-enenitrile
- EC Number:
- 257-288-8
- EC Name:
- 3,7-dimethyloct-6-enenitrile
- Cas Number:
- 51566-62-2
- Molecular formula:
- C10H17N
- IUPAC Name:
- 3,7-dimethyloct-6-enenitrile
- Details on test material:
- - Name of test material (as cited in study report): Citronellal Nitril, #04526, J79-261 (no further data)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 6 to 8 weeks
- Weight at study initiation: 200-266g
- Fasting period before study: 18 hours
- Housing: Galvanized cages with indirect bedding
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: At least two days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 3150, 3960, 4460, 6300, 7940 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- The acute oral toxicity of the test material was evaluated in 6-8 week old Wistar strain albino rats weighing 200-266g. The rats were dosed singly in groups of six per dose level. Animals were observed for signs of toxicity and mortality at 1, 3, 6 and 24 hours following dosing. Observations were made at least once daily thereafter for a total of 14 days. All surviving animals were sacrificed at the end of day 14, weighed and gross necropsy was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 490 mg/kg bw
- 95% CL:
- >= 3 740 - <= 5 390
- Mortality:
- - 3150 mg/kg bw: 1/3 males, 0/3 females died.
- 3960 mg/kg bw: 1/3 males; 1/3 females died.
- 4460 mg/kg bw: 3/3 males; 2/3 females died.
- 6300 mg/kg bw: 3/3 males; 2/3 females died.
- 7940 mg/kg bw: 2/3 males; 3/3 females died. - Clinical signs:
- other: - 3150 mg/kg bw: Clinical signs were normal. One animal died btw. day 7-14. - 3960 mg/kg bw: One animal showed slight depression for 24 hours, but recovered within 2 days. One animal died within two days and one animal died within 5 days. - 4460 mg/kg bw:
- Gross pathology:
- - 3150 mg/kg bw: The one animal that died had fibrous tissue encasing heart and lungs. In the other animals no gross pathology changes were observed.
- 3960 mg/kg bw: One of the four surviving animals showed fibrous tissue encasing the heart and lungs. In one of two animals that died during the observation period the following observations were made: head partially cannibalized, pyloric mucosa severely reddened, stomach ruptured, all abdominal viscera adhered to body wall and covered with a thin layer of fibrous tissue.
- 4460 mg/kg bw: In one animal which died during the observation period, a extremely pale liver and ruptured intestines were observed. Two other animals which died during the observation period where partially cannibalized.
- 6300 mg/kg bw: In three animals moderate reddened pyloric mucosa was observed. In the animal who died within one hour after treatment, test article was found in the stomach.
- 7940 mg/kg bw: One animal was partially cannibalized. In the other animals no gross pathology changes were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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