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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicity of antioxidants to tetrahymena pyriformis
Author:
Epstein SS, Saporoschetz IB, Hutner SH
Year:
1967
Bibliographic source:
J Protozool, Vol. 14 (2), 238-243

Materials and methods

Principles of method if other than guideline:
The cytotoxicity of 97 antioxidants of various structural types, among these the test substance, was determined for Tetrahymena pyriformnis grown in a peptone medium.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol
EC Number:
213-590-1
EC Name:
2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol
Cas Number:
991-84-4
Molecular formula:
C33H56N4OS2
IUPAC Name:
2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol

Results and discussion

Any other information on results incl. tables

The test substance had low toxicity to Tetrahymena pyriformis (median ID50: >1000 µg/ml) and low toxicity to rat (LD50: >5 g/kg bw) as well as high antioxidant activity by the photodynamic test when related to d-a-Tocopherol (value 3.1 for the test substance and 1 for tocopherol).

Applicant's summary and conclusion

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