Registration Dossier
Registration Dossier
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EC number: 270-096-9 | CAS number: 68411-04-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to scientifically accepted protocol; no GPL; conducted in 1976
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Compound was delivered to the inner-ear skin of 2 rabbits for 24 hours.
Dose: 500 mg/animal
semiocclusive treatment; compound fixed with an adhesive bandage for 24 hours; animals were observed for 7 days. - GLP compliance:
- no
Test material
- Reference substance name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs.
- EC Number:
- 270-096-9
- EC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs.
- Cas Number:
- 68411-04-1
- Molecular formula:
- [C32H16CuN8][O3S]n[C5H12N2O2S]m
- IUPAC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-.kappa.N29,.kappa.N30,.kappa.N31,.kappa.N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs.
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: inner-ear skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at 24 and 48 hrs.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at 24 and 48 hrs..
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at 24 and 48 hrs.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at 24 and 48 hrs.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- >= 0
- Max. score:
- 4
- Reversibility:
- other: not measured/tested
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- >= 0
- Max. score:
- 4
- Reversibility:
- other: not measured/tested
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
No irritation observed at any time point: 0, 24 and 48 h.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No irritation observed at any time point: 0, 24 and 48 h.
- Executive summary:
No irritation observed at any time point: 0, 24 and 48 h.
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