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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The skin sensitization potential of resorcinol: experience with the local lymph node assay
Author:
Basketter DA, Sanders D, Jowsey IR
Year:
2007
Bibliographic source:
Contact Dermatitis 56:196-200.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Reference substance name:
Resorcinol
Cas Number:
Resorcinol
Molecular formula:
C6H6O2
IUPAC Name:
Resorcinol
Constituent 2
Reference substance name:
1,3-Benzenediol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
1,3-Benzenediol
Constituent 3
Chemical structure
Reference substance name:
Resorcinol
EC Number:
203-585-2
EC Name:
Resorcinol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
1,3 benzenediol
Details on test material:
- Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid

In vivo test system

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
0 (AOO), 0.1, 0.25, 0.5, 1.0, 2.5 % w/v resorcinol

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: see Remark
Remarks:
All disintegrations per minute (d.p.m.)/node values obtained with the test substance are lower than that obtained with the vehicle control, resulting in SI values of <1 in all cases. AOO vehicle control values are considered high. Treatment Conc=(%w/v) Conc%, 0 (AOO), SI = 1.0 Conc% 0.1%, SI = 0.4 Conc% 0.25, SI = 0.2 Conc% 0.5, SI = 0.5 Conc% 1.0, SI = 0.8 Conc% 2.5, SI = 1.0
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: see Remark
Remarks:
All disintegrations per minute (d.p.m.)/node values obtained with the test substance are lower than that obtained with the vehicle control, resulting in SI values of <1 in all cases. AOO vehicle control values are considered high. Treatment Conc=(%w/v) Conc%, 0 (AOO), d.p.m./lymph node = 1120 Conc% 0.1%, d.p.m./lymph node = 443 Conc% 0.25, d.p.m./lymph node = 250 Conc% 0.5, d.p.m./lymph node = 566 Conc% 1.0, d.p.m./lymph node = 849 Conc% 2.5, d.p.m./lymph node = 1100

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance rescorcinol was found to be not sensitizing to skin of mouse when applied at consentration of 0 (AOO), 0.1, 0.25, 0.5, 1.0, 2.5 % w/v in acetone/olive oil (4:1) vehicle
Executive summary:

The substance rescorcinol was found to be not sensitizing to skin of mouse when applied at consentration of 0 (AOO), 0.1, 0.25, 0.5, 1.0, 2.5 % w/v in acetone/olive oil (4:1) vehicle.