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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The skin sensitization potential of resorcinol: experience with the local lymph node assay
Author:
Basketter DA, Sanders D, Jowsey IR
Year:
2007
Bibliographic source:
Contact Dermatitis 56:196-200.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid

In vivo test system

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
0 (AOO), 0.1, 0.25, 0.5, 1.0, 2.5 % w/v resorcinol

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: see Remark
Remarks:
All disintegrations per minute (d.p.m.)/node values obtained with the test substance are lower than that obtained with the vehicle control, resulting in SI values of <1 in all cases. AOO vehicle control values are considered high. Treatment Conc=(%w/v) Conc%, 0 (AOO), SI = 1.0 Conc% 0.1%, SI = 0.4 Conc% 0.25, SI = 0.2 Conc% 0.5, SI = 0.5 Conc% 1.0, SI = 0.8 Conc% 2.5, SI = 1.0
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: see Remark
Remarks:
All disintegrations per minute (d.p.m.)/node values obtained with the test substance are lower than that obtained with the vehicle control, resulting in SI values of <1 in all cases. AOO vehicle control values are considered high. Treatment Conc=(%w/v) Conc%, 0 (AOO), d.p.m./lymph node = 1120 Conc% 0.1%, d.p.m./lymph node = 443 Conc% 0.25, d.p.m./lymph node = 250 Conc% 0.5, d.p.m./lymph node = 566 Conc% 1.0, d.p.m./lymph node = 849 Conc% 2.5, d.p.m./lymph node = 1100

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance rescorcinol was found to be not sensitizing to skin of mouse when applied at consentration of 0 (AOO), 0.1, 0.25, 0.5, 1.0, 2.5 % w/v in acetone/olive oil (4:1) vehicle
Executive summary:

The substance rescorcinol was found to be not sensitizing to skin of mouse when applied at consentration of 0 (AOO), 0.1, 0.25, 0.5, 1.0, 2.5 % w/v in acetone/olive oil (4:1) vehicle.