3-diethylaminophenol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS

Author:

G. K. LLOYD, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES

Year:

1977

Bibliographic source:

Fd Cosmet. Toxicol. Vol. 15, pp. 607-610 1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Acute toxicity of resorcinol was assessed in CFY rats in a 14 days study

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Resorcinol

Cas Number:

Resorcinol

Molecular formula:

C6H6O2

IUPAC Name:

Resorcinol

Constituent 2

Reference substance name:

1,3-Benzenediol

Cas Number:

108-46-3

Molecular formula:

C6H6O2

IUPAC Name:

1,3-Benzenediol

Constituent 3

Reference substance name:

Resorcinol

EC Number:

203-585-2

EC Name:

Resorcinol

Cas Number:

108-46-3

Molecular formula:

C6H6O2

IUPAC Name:

1,3 benzenediol

Details on test material:

- Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:

rat

Strain:

other: CFY

Sex:

male/female

Administration / exposure

Route of administration:

other: oral intubation

Vehicle:

water

Details on oral exposure:

The animals were starved overnight before treatment.

Doses:

370 mg/kg bw

No. of animals per sex per dose:

5 /sex and group

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: deaths and signs of toxicity, microscopic evaluation, other:

Statistics:

The LDso and its 95% confidence limits were calculated from the mortality data either by the method of Litchfield & Wilcoxon (1949) or by that of Weil (1952).

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

370 mg/kg bw

Based on:

test mat.

Mortality:

Mortality was observed

Clinical signs:

other: Dosed animals showed lethargy and piloerection,

Gross pathology:

no adverse findings were reported

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute Oral LD50 value of resorcinol in CFY rats in 14 days observation period was found to be 370 mg/kg bw

Executive summary:

The acute Oral LD50 value of resorcinol in CFY rats in 14 days observation period was found to be 370 mg/kg bw. Dosed animals showed lethargy and piloerection, whereas no adverse findings were reported at sacrifice (14 days).

This value indicates that resorcinol exhibits acute toxicity by the oral route in the Category 3