Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS
Author:
G. K. LLOYD, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES
Year:
1977
Bibliographic source:
Fd Cosmet. Toxicol. Vol. 15, pp. 607-610 1977

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Acute toxicity of resorcinol was assessed in CFY rats in a 14 days study
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
other: CFY
Sex:
male/female

Administration / exposure

Route of administration:
other: oral intubation
Vehicle:
water
Details on oral exposure:
The animals were starved overnight before treatment.
Doses:
370 mg/kg bw
No. of animals per sex per dose:
5 /sex and group
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: deaths and signs of toxicity, microscopic evaluation, other:
Statistics:
The LDso and its 95% confidence limits were calculated from the mortality data either by the method of Litchfield & Wilcoxon (1949) or by that of Weil (1952).

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
370 mg/kg bw
Based on:
test mat.
Mortality:
Mortality was observed
Clinical signs:
Dosed animals showed lethargy and piloerection,
Body weight:
not examined
Gross pathology:
no adverse findings were reported

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute Oral LD50 value of resorcinol in CFY rats in 14 days observation period was found to be 370 mg/kg bw
Executive summary:

The acute Oral LD50 value of resorcinol in CFY rats in 14 days observation period was found to be 370 mg/kg bw. Dosed animals showed lethargy and piloerection, whereas no adverse findings were reported at sacrifice (14 days).

This value indicates that resorcinol exhibits acute toxicity by the oral route in the Category 3